NatraGest 56g(Please allow 2 weeks of delivery) Research has shown that Progesterone is most effectively administered transdermally as a creme. This way it bypasses the digestive system, which breaks it down before it has a chance to reach the blood stream. Natural Progesterone can help bring the Progesterone Estrogen ratios back into balance, thus helping to reduce these symptoms. It may also help to maintain normal bone density, which otherwise starts to decline